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McClellan AJ, Volpe EA, Zhang X, Darlington GJ, Li DQ, Pflugfelder SC, et al

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Rather, evidence for these alterations has been collected piecemeal, limiting the potential to inform our understanding of the interactions amongst relevant biochemical pathways

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And it is worth noting that many KRas-dependent tumors develop resistance to mTORC1 inhibition by upregulating glutamine metabolism, but the combination of mTORC1 inhibition with CB-839 can overcome this resistance [110]